Angiotensinaren entzima bihurtzailea 2

ACE2
Proteinak kodetzen dituen genea
Identifikadoreak
Homologene: 41448 Genenames: ACE2 Ensemble: ENSG00000130234
Taxoia	Homo sapiens
Kokapena
Kromosoma	giza X kromosoma
Kokapen zitogenetikoa	Xp22.2
Hasiera	15561033 bp[1]
Amaiera	15602148 bp[2]
Transkripzioak
RNA ID	NM_021804 eta NM_001371415
Ensembl	Zerrenda ENST00000484756 ENST00000252519 ENST00000427411 ENST00000471548 ENST00000473851
Beste espezieetan
Sagu arrunt	Ace2 (en)
Arratoi arrunt	Ace2 (en)
Caenorhabditis elegans	acn-1 (en)
Danio rerio	ace2 (en)
Gene-adierazpen eredua
eta
Ontologia
Kodetzen du	angiotensin I converting enzyme 2 (en)
Funtzio-molekularrak	Ikusi peptidyl-dipeptidase activity (en) virus receptor activity (en) zinc ion binding (en) endopeptidase activity (en) metal ion binding (en) peptidase activity (en) proteina lotura carboxypeptidase activity (en) hydrolase activity (en) metallopeptidase activity (en) metallocarboxypeptidase activity (en) carboxypeptidase activity (en) exopeptidase activity (en)
Osagai-zelularra	Ikusi zitoplasma zelula-mintzaren osagai integrala mintza zelula mintz zelulaz kanpoko eremu cell surface (en) lipido baltsa extracellular exosome (en) extracellular space (en) extracellular space (en) zelula mintz brush border membrane (en) extracellular exosome (en)
Prozesu-biologikoak	Ikusi regulation of cardiac conduction (en) angiotensin-mediated drinking behavior (en) proteolisi regulation of cytokine production (en) positive regulation of reactive oxygen species metabolic process (en) regulation of vasoconstriction (en) regulation of cell population proliferation (en) positive regulation of cardiac muscle contraction (en) regulation of inflammatory response (en) positive regulation of gap junction assembly (en) viral entry into host cell (en) viral process (en) regulation of systemic arterial blood pressure by renin-angiotensin (en) tryptophan transport (en) blood vessel diameter maintenance (en) angiotensin maturation (en) receptor-mediated virion attachment to host cell (en) angiotensin maturation (en) regulation of systemic arterial blood pressure by renin-angiotensin (en) positive regulation of amino acid transport (en)

Angiotensinaren entzima bihurtzailea 2^[3][4] (ACE2) birika, arteria, bihotz, giltzurrun eta hesteetako zeluletako zelula-mintzei atxikitako entzima bat da^[5][6]. ACE2ak odol-presioa txikiagotzen du angiotensina II peptido baso-uzkurtzailearen hidrolisia katalizatuz, angiotensina (1-7) sortuz, hodi-zabaltzaile bat^[7][8][6]. ACE2ak bere antzekoa den angiotensinaren entzima bihurtzailearen (ACE) ekintzari aurka egiten dio^[9], eta horregatik gaixotasun kardiobaskularren aurkako botiken helburu interesgarria da^[9][10].

ACE2 koronabirus batzuen sarrera puntua ere izan ohi da, nabarmen HCoV-NL63, SARS-CoV, eta SARS-CoV-2^[11]. Batzuetan, gizakien ACE2 entzimari hACE2 deritzo^[12].

1. ↑ GRCh38: Ensembl release 89: ENSG00000130234. Ensembl.
2. ↑ GRCh38: Ensembl release 89: ENSG00000130234. Ensembl.
3. ↑ «Volumen 8. BIT: 8 alea, 4. zenbakia, 2000eko azaroa - navarra.es» www.navarra.es (Noiz kontsultatua: 2020-12-08).
4. ↑ Kardiologia hiztegia. .
5. ↑ (Ingelesez) Hamming, I.; Timens, W.; Bulthuis, M. L. C.; Lely, A. T.; Navis, G. J.; Goor, H. van. (2004). «Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis» The Journal of Pathology 203 (2): 631–637.  doi:10.1002/path.1570. ISSN 1096-9896. PMID 15141377. PMC PMC7167720. (Noiz kontsultatua: 2020-12-08).
6. ↑ ^{a b} Donoghue Mary; Hsieh Frank; Baronas Elizabeth; Godbout Kevin; Gosselin Michael; Stagliano Nancy; Donovan Michael; Woolf Betty et al.. (2000-09-01). «A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9» Circulation Research 87 (5): e1–e9.  doi:10.1161/01.RES.87.5.e1. (Noiz kontsultatua: 2020-12-08).
7. ↑ (Ingelesez) Keidar, Shlomo; Kaplan, Marielle; Gamliel-Lazarovich, Aviva. (2007-02-01). «ACE2 of the heart: From angiotensin I to angiotensin (1–7)» Cardiovascular Research 73 (3): 463–469.  doi:10.1016/j.cardiores.2006.09.006. ISSN 0008-6363. (Noiz kontsultatua: 2020-12-08).
8. ↑ Wang Wang; McKinnie Shaun M.K.; Farhan Maikel; Paul Manish; McDonald Tyler; McLean Brent; Llorens-Cortes Catherine; Hazra Saugata et al.. (2016-08-01). «Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17» Hypertension 68 (2): 365–377.  doi:10.1161/HYPERTENSIONAHA.115.06892. (Noiz kontsultatua: 2020-12-08).
9. ↑ ^{a b} (Ingelesez) Chamsi-Pasha, Mohammed A. R.; Shao, Zhili; Tang, W. H. Wilson. (2014-03-01). «Angiotensin-Converting Enzyme 2 as a Therapeutic Target for Heart Failure» Current Heart Failure Reports 11 (1): 58–63.  doi:10.1007/s11897-013-0178-0. ISSN 1546-9549. PMID 24293035. PMC PMC3944399. (Noiz kontsultatua: 2020-12-08).
10. ↑ (Ingelesez) Mascolo, Annamaria; Urbanek, Konrad; De Angelis, Antonella; Sessa, Maurizio; Scavone, Cristina; Berrino, Liberato; Rosano, Giuseppe Massimo Claudio; Capuano, Annalisa et al.. (2020-03-01). «Angiotensin II and angiotensin 1–7: which is their role in atrial fibrillation?» Heart Failure Reviews 25 (2): 367–380.  doi:10.1007/s10741-019-09837-7. ISSN 1573-7322. (Noiz kontsultatua: 2020-12-08).
11. ↑ «ACE2 angiotensin I converting enzyme 2 [Homo sapiens (human) - Gene - NCBI»] www.ncbi.nlm.nih.gov (Noiz kontsultatua: 2020-12-08).
12. ↑ Emerging and reemerging viral pathogens. Volume 1, Fundamental and basic virology aspects of human, animal and plant pathogens. Academic Press 2020 ISBN 978-0-12-819401-0. PMC 1120973177. (Noiz kontsultatua: 2020-12-08).